CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G04247) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme and iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with ergosterol, mycophenolic acid, cichorine, terpenoid, and secondary metabolite biosynthesis, and localises to the endoplasmic reticulum membrane. Phenotypic associations include decreased colony size, increased cell death, arrested vegetative growth, decreased meiosis, abnormal autophagy, decreased mating response, abnormal plasma membrane and cytoskeleton morphology, and increased budding. The gene is also linked to abnormal vacuolar transport, decreased endocytosis, absent micronucleophagy, and delayed cell cycle progression through G2/M phase. Related genes in other species connect the family to cytochrome P450 oxidoreductase function and potassium concentration.