ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G04559) on chromosome 1 of Fusarium graminearum PH-1 encodes an ABC-type transporter with ATP hydrolase activity, ATP binding, and transmembrane transporter activity, belonging to the type I exporter family. The gene is associated with oligopeptide export from the mitochondrion, xenobiotic detoxification across the plasma membrane, response to antibiotics and toxic substances, sterol anabolism, secretion, membrane transport, and homeostasis. Its product localises to the fungal-type vacuole, mitochondrial inner membrane, mitochondria, and plasma membrane. Phenotypic associations include decreased hypoosmotic stress resistance, increased pexophagy, abnormal cell cycle progression, decreased endocytosis rate, increased entry into G0 stationary phase, and abnormal vacuolar morphology and distribution. Studies of related genes in other species link the family to oxidative stress response.