OGM2 — Fusarium graminearum PH-1

Summary

FgOGM2 (FGRAMPH1_01G03745) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with protein O-mannosyltransferase, mannosyltransferase, and transglycosidase activities, belonging to the PMT_4TMC and ArnT-like_N domain families. The gene is associated with protein O-linked mannosylation, regulation of ER unfolded protein response, downregulation of proteolysis, filamentous growth, cell-substrate adhesion, fungal-type cell wall organization, and interaction with host. It is linked to the endomembrane system, ER membrane, nuclear membrane, and plasma membrane. Associations include abnormal chitin deposition, septum formation, plasma membrane morphology, decreased pheromone sensitivity, delayed endocytosis and cytokinesis, and altered cell cycle progression. Studies of related genes in other species link the family to mannose content, reduced virulence, and loss of pathogenicity.