ATG27 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03835, the Fusarium graminearum PH-1 orthologue of ATG27 on chromosome 1, encodes an autophagy-related protein 27 containing a mannose-6-phosphate isomerase receptor-binding domain superfamily and an MRH domain. The gene product binds phosphatidylinositol-3-phosphate and is associated with vacuolar transport, pexophagy, sporulation, morphogenesis, protein transport, and autophagy. It localises to clathrin-coated vesicles, the trans-Golgi network, cytoplasmic vesicle membranes, the pre-autophagosomal structure membrane, mitochondrial membranes, vacuolar membranes, and Golgi membranes. Studies of related genes in other species link the ATG27 family to autophagy and vacuolar trafficking pathways.