OTA — Fusarium graminearum PH-1

Summary

FgOTA (FGRAMPH1_01G03833) on chromosome 1 of Fusarium graminearum PH-1 encodes a pyridoxal phosphate-dependent aminotransferase with N2-acetylornithine 5-aminotransferase and L-ornithine transaminase activities, placing it in the Class-III PLP-dependent aminotransferase family. The gene is associated with ornithine metabolism, arginine anabolism, the urea cycle, and L-proline biosynthesis, and its product localises to the mitochondrial lumen, cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal cell cycle progression, altered endocytosis, increased flocculation and biofilm formation, decreased freeze-thaw and ionic stress resistance, and changes in nutrient uptake and utilisation. The gene is also linked to autophagy, sporulation, and actin cytoskeleton morphology. Studies of related genes in other species connect the family to filamentous growth, thermotolerance, and protein content.