TNG — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03595 (TNG, also known as SIT4) in Fusarium graminearum PH-1 encodes a protein serine/threonine phosphatase with a calcineurin-like phosphoesterase domain and metal-binding activity. The gene is associated with the regulation of TORC1 signaling, actin cytoskeleton organization, fungal-type cell wall organization, and filamentous growth in response to chemical stimuli, heat, and neutral pH. It is linked to cell cycle progression, including negative regulation of the DNA damage checkpoint and positive regulation of non-homologous end joining, as well as upregulation and downregulation of sister chromatid cohesion. Localization evidence connects the product to the PP2A complex, protein phosphatase 4 complex, chromatin, and the nuclear periphery. Phenotypic associations include increased virulence, altered alkaline pH resistance, abnormal cell cycle arrest, and changes in budding and replicative lifespan. Related genes in other species are linked to reduced virulence and abnormal fermentative and respiratory metabolism.