ADA1 — Fusarium graminearum PH-1

Summary

FgADA1 (FGRAMPH1_01G03383) on chromosome 1 of Fusarium graminearum PH-1 encodes an AMP deaminase, a metal-binding hydrolase of the AMPD family. The gene is associated with AMP metabolism, IMP salvage and anabolism, RNA breakdown, methylation and demethylation processes, as well as sexual reproduction and hyphal growth, and its product localises to the cytosol. Associations with numerous phenotypes include increased freeze-thaw resistance, decreased cold sensitivity, increased respiratory metabolism, altered fermentative metabolism, absent budding and cytokinesis, decreased meiosis, abnormal mating projection and Golgi morphology, and decreased nutrient uptake and phosphorus utilization. Studies of related genes in other species link the AMP deaminase family to oxidative stress response, delayed budding and increased biofilm formation.