CCH1 — Fusarium graminearum PH-1

Summary

FgCCH1 (FGRAMPH1_01G03365) on chromosome 1 of Fusarium graminearum PH-1 encodes a voltage-sensitive calcium channel with high voltage-gated calcium channel activity, stretch-activated monoatomic cation-selective calcium channel activity, and calcium ion binding. It contains a VDCC alpha-1 subunit domain, and localises to the plasma membrane as part of a voltage-gated calcium channel complex. The gene is associated with ascus development, calcium ion import, mating, and filamentous growth. Phenotypic associations include abnormal cell fusion, absent or decreased recovery from pheromone-induced cell cycle arrest, abnormal Golgi distribution, decreased budding, absent bipolar budding, absent mating-type switching, decreased necrotic cell death, and increased alkaline pH resistance. Studies of related genes in other species link the family to calcium sensitivity, acid sensitivity, oxidative stress response, and reduced virulence.