VELB — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03357 (symbol VELB, also known as velB) in Fusarium graminearum PH-1 on chromosome 1 encodes a protein containing a Velvet domain, placing it in the Velvet family of fungal regulatory proteins. The gene is associated with the regulation of secondary metabolism, including positive regulation of sterigmatocystin biosynthesis and ergosterol anabolism, as well as mycose biosynthesis and pigmentation. It is linked to sexual reproduction, mating, and positive regulation of sexual sporulation, while being negatively associated with conidium formation. VELB is associated with cellular responses to light stimulus and activity, immune response, and the MAPK cascade. The protein localises to both the cytoplasm and nucleus. Studies of related genes in other species link the family to sporogenesis, oxidative stress response, and reduced virulence.