PMT3 — Fusarium graminearum PH-1

Summary

FgPMT3 (FGRAMPH1_01G03267) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing a Rad60/SUMO-like domain and a ubiquitin-like domain. The gene product is associated with E3 protein ligase binding and protein tag activity. FgPMT3 is linked to sumoylation, DNA damage response, telomere maintenance, stalled replication fork localization to the nuclear periphery, mitotic recombination-dependent replication fork processing, sporulation, and chromatin modeling. It localizes to the nucleus, mitotic spindle pole body, linear element, and septin ring. The gene is associated with numerous phenotypes including delayed growth, abnormal cell cycle progression, defective chromosome segregation, altered meiotic and mitotic recombination, abnormal telomere length, impaired sporulation, and reduced virulence. Studies of related genes in other species link the family to reduced virulence.