ACYA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G03055 (ACYA) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with adenylyl cyclase activity, poly(A)-specific RNase activity, and binding capabilities for ATP, RNA, and metal ions. It contains adenylate cyclase, leucine-rich repeat, and PPM-type phosphatase-like domains. The gene is associated with cAMP anabolism, the glucose-sensing PKA pathway, sexual reproduction, sporulation, DNA replication checkpoint, and both positive and negative regulation of transcription by RNA polymerase II. It localizes to the plasma membrane, cytoplasm, P-body, and CCR4-NOT and Paf1 complexes. Associations include increased necrotic cell death, decreased lifespan, abnormal filamentous and pseudohyphal growth, increased adhesion and fermentative growth, altered cell cycle progression through G2/M, and abnormal spore germination and pheromone sensitivity. Studies of related genes in other species link the family to loss of pathogenicity, reduced virulence, and unaffected pathogenicity.