BRR2 — Fusarium graminearum PH-1

Summary

FgBRR2 (FGRAMPH1_01G02993) on chromosome 1 of Fusarium graminearum PH-1 encodes a DEAD/DEAH-box helicase with RNA helicase activity, ATP binding and hydrolysis, and nucleic acid binding. The protein contains multiple domains including the BRR2_plug, Brr2_helicase_PWI, and helicase ATP-binding and C-terminal domains. FgBRR2 is associated with spliceosome conformational changes that release U4 and generate the catalytic conformation, mRNA cis splicing via the spliceosome, sno(s)RNA and rRNA processing, polyuridylation-dependent mRNA catabolism, nuclear mRNA surveillance, heterochromatin island assembly, and degradation of meiosis-specific transcripts. It localises to the U5 snRNP, U4/U6.U5 snRNP complex, spliceosome, nucleolus, nuclear body, and RQT, Ski, and NURS complexes. The gene is linked to abnormal spore germination, delayed chromosome segregation, increased polyploidy, and altered cell cycle progression, mating, and vacuolar distribution.