PEX5 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G02915, designated FgPEX5 on chromosome 1 of Fusarium graminearum PH-1, encodes a PEX5/PEX5L family peroxin-5 protein with tetratricopeptide repeats (TPR_rpt, TPR-like_helical_dom_sf) that is associated with PTS1 binding, protein carrier activity, and protein binding, bridging. The gene is associated with peroxisomal matrix protein import and docking, fatty acid beta-oxidation, pexophagy, detoxification, cell death, and homeostasis. It localises to the peroxisomal import pore, lumen, and membrane, as well as the cytosol. Associations include abnormal peroxisomal morphology and distribution, absent peroxisomal transport, increased pheromone sensitivity and mating response, premature cell cycle progression, altered budding patterns, decreased respiratory metabolism, and increased lifespan. Related genes in other species link the family to reduced virulence and associations with fusarium head blight and ear rot in wheat and maize.