COT1 — Fusarium graminearum PH-1

Summary

FgCOT1 (FGRAMPH1_01G02387) on chromosome 1 of Fusarium graminearum PH-1 encodes a member of the cation efflux family, possessing zinc ion transmembrane transporter activity and zinc ion sequestering activity. The gene is associated with cellular zinc ion homeostasis, including detoxification of zinc ions and zinc ion import into the ER, Golgi lumen, and other organelles. It has been linked to hyphal growth, morphogenesis, cell differentiation, cell wall organization, lipid metabolism, secondary metabolite biosynthesis, and RNA metabolism. The encoded protein localizes to the ER, Golgi, vacuolar, and nuclear membranes, as well as cytoplasmic vesicles. Associations with increased ionic stress and UV resistance, altered sporulation, abnormal budding and cellular morphology, and defects in autophagy, endocytosis, and mitochondrial genome maintenance have been reported.