BUB2 — Fusarium graminearum PH-1

Summary

FgBUB2 (FGRAMPH1_01G02659) in Fusarium graminearum PH-1 encodes a protein containing a Rab-GAP TBC domain. The gene is associated with negative regulation of division septum assembly, regulation of septation initiation network, downregulation of mitotic cytokinesis, downregulation of septation initiation signaling, mitotic exit, nuclear division, hyphal growth, secretion, and the cell cycle. The encoded product localizes to the SIN/MEN two-component GAP complex, old SPB, meiotic spindle pole body, mitotic spindle pole body, cytosol, and nucleus. Phenotypic associations link FgBUB2 to abnormal cell cycle progression, including premature metaphase-anaphase transition, altered anaphase timing, increased sporulation, decreased flocculation, increased mating efficiency, abnormal nuclear fusion during mating, decreased lifespan, and abnormal bipolar budding. Studies of related genes in other species connect the family to mitotic checkpoint functions.