ILV1 — Fusarium graminearum PH-1

Summary

FgILV1 (FGRAMPH1_01G02707) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with acetolactate synthase large subunit and thiamine pyrophosphate-binding domains, and is associated with acetolactate synthase, pyruvate decarboxylase, and 2-hydroxyacyl-CoA lyase activities. It is associated with valine, L-isoleucine, and L-leucine anabolism, fatty acid alpha-oxidation, pigmentation, hyphal growth, morphogenesis, and hypersensitivity. The protein localises to the acetolactate synthase complex, peroxisomes, mitochondria, cytosol, nucleus, and fungal biofilm matrix. Phenotypic associations include altered vegetative growth, sporulation, filamentous growth, cell cycle progression, osmotic stress resistance, autophagy, viability, fermentative metabolism, and prion formation. Related genes in other species are linked to loss of pathogenicity.