FMAG — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G02507 (FMAG, also known as Cyp51B) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 sterol 14-demethylase with methyltransferase activity, iron and heme binding, and redox activity. The protein localizes to the ER membrane and membrane. It is associated with sterol and ergosterol anabolism, demethylation, methylation, lipid metabolism, mycotoxin anabolism, conidium germination, conidia formation, sporulation, sexual reproduction, pyruvate metabolism, and glutamate metabolism. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; abnormal cell cycle progression through G2/M and S phases; increased cell death; arrested vegetative and exponential-phase growth; decreased invasive growth, shmoo formation, and nutrient uptake; and altered ER and Golgi distribution. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity.