PCN — Fusarium graminearum PH-1

Summary

FgPCN (FGRAMPH1_01G02633) on chromosome 1 of Fusarium graminearum PH-1 encodes a proliferating cell nuclear antigen (PCNA) family protein that functions as a processivity clamp and DNA-binding protein. This gene is associated with DNA replication and repair processes, including leading and lagging strand elongation, error-free translesion synthesis, mismatch repair, and DNA damage tolerance. It is linked to mycotoxin anabolism, spore germination, and cell cycle progression, particularly the G1/S phase transition. The encoded protein localizes to the PCNA complex, nuclear replication fork, and sites of double-strand breaks. Phenotypic associations include altered resistance to X-rays and chemicals, delayed cell cycle progression, abnormal prion inheritance, and effects on meiotic recombination and chromosome segregation. Related genes in other species link it to additional DNA repair and replication functions.