LSP1 — Fusarium graminearum PH-1

Summary

FgLSP1 (FGRAMPH1_01G02265) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein of the PIL1/LSP1 family containing an AH/BAR domain superfamily domain and is annotated with lipid binding molecular function. The gene is associated with eisosome assembly, endocytosis, homeostasis, and mycotoxin anabolism, and its product localizes to the eisosome, plasma membrane, ascus membrane, prospore membrane leading edge, and meiotic spindle pole body. Phenotypic associations include abnormal spore germination, absent or decreased cell fusion, absent meiosis, decreased endocytosis and cytokinesis, increased necrotic cell death, abnormal filamentous growth, and altered pheromone sensitivity and cell cycle progression. Studies of related genes in other species link the family to reduced virulence and linear eisosome formation.