CLR6 — Fusarium graminearum PH-1

Summary

FgCLR6 (FGRAMPH1_01G01959) on chromosome 1 of Fusarium graminearum PH-1 encodes a histone deacetylase of the His_deacetylse_1 family, with demonstrated histone H4-K16, H4-K12, H4K5, H4K8, H3-K9, and H3-K14 deacetylase activities, as well as general protein deacetylase activity and chromatin binding. The gene is associated with epigenetic downregulation of gene expression, chromatin silencing including centromeric, telomeric, and rDNA heterochromatin assembly, and regulation of phenotypic switching. It is linked to filamentous growth in response to pH, starvation, and biotic stimuli, and to sexual reproduction. The product localizes to multiple chromatin-modifying complexes including HDA1, Rpd3S, SHREC, SET3C, and Clr6-LE. Phenotypic associations include abnormal cell cycle progression, mating-type switching, sporulation rate, biofilm formation, and pheromone sensitivity. Studies of related genes in other species link it to acid sensitivity.