GWT1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G01765 (GWT1) in Fusarium graminearum PH-1 encodes a glucosaminyl-phosphatidylinositol O-acyltransferase, a member of the PIGW/GWT1 family, and is localized to the endoplasmic reticulum membrane. This gene is associated with GPI anchor anabolism and protein localization to the plasma membrane. Phenotypic associations link GWT1 to abnormal flocculation, cytokinesis, and endomembrane system morphology, as well as decreased vegetative growth, budding, and mating efficiency. It is also connected to increased chitin deposition and telomere length, altered cell cycle progression including G1 phase abnormalities and S phase delay, and reduced cold sensitivity and survival in stationary phase. Additional associations include abnormal RNA accumulation, spindle morphology absence, and altered carbon and nitrogen source utilization. Studies of related genes in other species connect the family to abnormal cell size, shape, and cell wall morphology.