CKA — Fusarium graminearum PH-1

Summary

FgCKA (FGRAMPH1_01G01705) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a CK2_alpha domain and protein serine/threonine kinase activity, dual-specificity protein kinase activity, and cyclin, calmodulin, and chromatin binding. The gene is associated with regulation of nuclear cell cycle DNA replication, mRNA splicing, transcription by RNA polymerases I and III, bipolar cell polarity, phospholipid anabolism, calcium-mediated signaling, osmolarity sensing, nucleocytoplasmic transport, glycogen anabolism, exit from mitosis, macroautophagy, cell division, and stress-activated MAPK cascades. The product localizes to the casein kinase II complex, nucleolus, division septum, cellular bud neck, mitotic spindle pole body, and cell tip. Phenotypic associations include increased thermotolerance, delayed vegetative growth, abnormal G1/S phase transition, decreased cell death, absent meiosis and nuclear fusion during mating, and increased freeze-thaw resistance.