ATB2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G01613 (ATB2, TUB1) in Fusarium graminearum PH-1 encodes an alpha tubulin, a structural constituent of the cytoskeleton that binds GTP and exhibits hydrolase activity. This gene is associated with microtubule-based processes, including microtubule cytoskeleton organization, mitotic spindle organization, nuclear migration, and cytoplasmic microtubule organization. It is linked to both asexual and sexual reproduction, specifically perithecium formation, ascospore formation, and hyphal growth, as well as mitochondrial distribution and RNA processing. The encoded protein localizes to microtubules, the spindle, and the cytoplasm. Phenotypic associations include abnormal colony size, spore germination, cell cycle progression, spindle morphology, and chromosome segregation, along with altered resistance to chemicals and anaerobic growth. Studies of related genes in other species link the family to loss of pathogenicity and lethal phenotypes.