CDCA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G01385 (CDCA, also known as FgCDC14) encodes a dual-specificity phosphatase with protein tyrosine/serine/threonine phosphatase activity, belonging to the CDC14 family. In Fusarium graminearum, this gene is associated with the regulation of cell septum assembly, division septum assembly, mitotic cytokinesis, and the mitotic cell cycle spindle assembly checkpoint. It is linked to meiotic spindle breakdown, negative regulation of mitotic entry, and positive regulation of mitotic sister chromatid biorientation. The encoded protein localizes to the RENT complex, mitotic spindle midzone, spindle pole body, actomyosin contractile ring, and primary cell septum. Phenotypic associations include temperature-sensitive growth, absent or decreased septum formation, increased sporulation, absent mating efficiency, and altered cell cycle progression through G1, G2, and anaphase. Studies of related genes in other species link the family to chromosome segregation and cell cycle control.