PTR1 — Fusarium graminearum PH-1

Summary

FgPTR1 (FGRAMPH1_01G01601) on chromosome 1 of Fusarium graminearum PH-1 encodes a HECT-type E3 ubiquitin ligase with ubiquitin-protein transferase activity and phospholipid binding. The gene is associated with protein polyubiquitination, ubiquitin-dependent proteolysis, autophagy, vacuolar transport, mRNA transport, and rRNA processing. It is linked to negative regulation of uracil import, downregulation of L-leucine import and Golgi-to-plasma membrane transport, and protein localization to the vacuole via the NVT and MVB pathways. Localization evidence connects the product to the cytoplasm, nucleus, nucleolus, Golgi complex, membrane, and cell periphery. Phenotypic associations include increased sporulation, abnormal cell cycle progression through G2/M and G1/S transitions, delayed chromosome segregation, increased freeze-thaw resistance, and altered nuclear size and export. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.