SCH9 — Fusarium graminearum PH-1

Summary

FgSCH9 (FGRAMPH1_01G01213) on chromosome 1 of Fusarium graminearum PH-1 encodes a serine/threonine protein kinase with protein kinase C activity, containing C2 domains and binding ATP, lipids, and zinc. The gene is associated with regulation of osmotic stress response, positive regulation of the cell integrity MAPK cascade, downregulation of TORC2 signaling, and positive regulation of transcription by RNA polymerase III. It is linked to cell cycle progression, including delayed anaphase and telophase, increased apoptosis, and spore germination. FgSCH9 is also associated with oxidative stress resistance, thermotolerance, nutrient uptake, and vacuolar morphology. Localization evidence places the product at the cytoskeleton, division septum, cell tip, stress granules, and nuclear envelope. Related genes in other species link the family to reduced virulence and oxidative stress response.