DBR1 — Fusarium graminearum PH-1

Summary

FgDBR1 (FGRAMPH1_01G00807) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing DBR1_C, Dbr1_N, and calcineurin-like phosphoesterase domains, with annotated metal binding and RNA lariat debranching enzyme activity. The gene is associated with mRNA splicing via the spliceosome, sexual reproduction, hyphal growth, protein synthesis, and homeostasis, and localises to the cytoplasm, nucleus, and spliceosome complex. Phenotypic associations include sterility, absent nuclear fusion during mating, absent mating response, absent shmoo formation, absent filamentous growth, altered pheromone sensitivity and production, decreased budding rate, and increased pseudohyphal growth. Studies of related genes in other species link the family to reduced virulence and decreased anaerobic growth.