CRL1 — Fusarium graminearum PH-1

Summary

FgCRL1 (FGRAMPH1_01G00811) on chromosome 1 of Fusarium graminearum PH-1 encodes a small GTPase of the Rho family, possessing GTPase activity, GTP and GDP binding, protein serine/threonine kinase activator activity, and signaling adaptor activity. This gene is associated with the positive regulation of primary cell septum biogenesis, actomyosin contractile ring contraction, formin-nucleated actin cable assembly, septum digestion after cytokinesis, and 1,3-beta-D-glucan biosynthetic processes. It is linked to Rho protein signal transduction, germ tube formation, cellular bud neck septin ring organization, and regulation of cell polarity and shape. The product localizes to the hyphal tip, growing cell tip, medial ring, and 1,3-beta-glucan synthase complex. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, including associations with Fusarium head blight.