SNX4 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G27793 (SNX4, also known as ATG24) in Fusarium graminearum PH-1 encodes a protein containing a PX domain and an AH/BAR domain superfamily, with molecular functions including phosphatidylinositol-3-phosphate binding and phosphoinositide binding. The gene is associated with numerous biological processes, particularly autophagy and its subtypes such as mitophagy, pexophagy, ER-phagy, and macroautophagy, as well as protein localization to the endosome, endocytic recycling, vacuolar transport, and actin polymerization. It is linked to the cytoplasm-to-vacuole targeting pathway, cellular homeostasis, and morphogenesis. The encoded protein localizes to the endosome membrane, early endosome, phagophore assembly site, mitochondria, and cytosol. Phenotypic associations include abnormal sporulation efficiency, decreased autophagy and pexophagy rates, delayed vacuolar transport, increased adhesion, and decreased cell death. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity.