FBP1 — Fusarium graminearum PH-1

Summary

FgFBP1 (FGRAMPH1_01G27481) on chromosome 4 of Fusarium graminearum PH-1 encodes a fructose-1,6-bisphosphatase, a class-1 FBPase with a conserved FBPtase domain and fructose 1,6-bisphosphate 1-phosphatase activity. The enzyme is associated with gluconeogenesis, fructose and sucrose anabolism, fructose 6-phosphate metabolism, and cellular response to glucose starvation. It localises to the cytoplasm, cytosol, and nucleus. The gene is linked to sexual reproduction, protein breakdown, and numerous phenotypes including abnormal meiosis, pseudohyphal growth, and colony shape; absent peroxisomal transport and morphology; increased hydrostatic pressure resistance and pheromone sensitivity; decreased nitrogen source utilisation and mitochondrial transport; and altered entry into G0 stationary phase, endocytosis, and silencing. Studies of related genes in other species connect the FBPase family to oxidative stress response.