BML — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G26865 (symbol BML, also known as TUB2 or FgTUB2) on chromosome 4 of Fusarium graminearum PH-1 encodes a beta-tubulin protein, a structural constituent of the cytoskeleton with GTPase activity, GTP binding and metal binding. The gene is associated with microtubule cytoskeleton organization, mitotic spindle organization, mitotic chromosome segregation, supramolecular fiber organization, hyphal growth, asexual and sexual reproduction, vacuole fusion, endocytosis, protein folding, and response to antibiotic. It is linked to numerous abnormal phenotypes including delayed exponential-phase growth, increased aneuploidy and polyploidy, premature or arrested meiosis, abnormal nuclear fusion during mating, absent apoptosis, and altered cell cycle progression through metaphase and anaphase. The gene also shows associations with colony size abnormality, delayed autophagy, and abnormal peroxisomal distribution.