HOG1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G26671 (HOG1) on chromosome 4 of Fusarium graminearum PH-1 encodes a mitogen-activated protein kinase (MAPK) of the p38/Hog1 family with protein serine/threonine kinase activity and ATP binding. The gene is associated with the stress-activated MAPK cascade, the cellular HOG (high osmolarity glycerol) response, and osmotic response. It is linked to infection cushion formation, conidium germination, pigmentation, and both asexual and sexual reproduction. Additional associations include RNA surveillance, RNA splicing, TOR signaling, lipogenesis, and sterol anabolism. The encoded protein localizes to the cytoplasm and nucleus. Phenotypic associations include absent osmotic stress resistance, decreased cell cycle progression rate, absent mating efficiency, and altered flocculation. Studies of related genes in other species link the family to virulence, germination rate, and oxidative stress response.