VPS17 — Fusarium graminearum PH-1

Summary

FgVPS17 (FGRAMPH1_01G26705) on chromosome 4 of Fusarium graminearum PH-1 encodes a vacuolar protein sorting-associated protein 17, a component of the retromer complex with a Vps17_PX domain that binds phosphatidylinositol-3-phosphate. The gene is associated with vesicle formation, retrograde transport from endosome to Golgi, vacuolar protein sorting, and ascospore formation. It localises to the retromer complex, SNX-BAR dimer, endosome, and FSM. Phenotypic associations include abnormal sporulation efficiency, decreased meiosis, arrested cell cycle progression in metaphase, delayed G1/S phase transition, absent mitophagy and pexophagy, decreased cold sensitivity, increased pseudohyphal growth, decreased mating response, and abnormal vacuolar transport. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.