LUA — Fusarium graminearum PH-1

Summary

FgLUA (FGRAMPH1_01G26727) on chromosome 4 of Fusarium graminearum PH-1 encodes a 3-isopropylmalate dehydratase, an enzyme with 3-isopropylmalate dehydratase and homoaconitate hydratase activities that binds 4Fe-4S clusters and metal ions. The gene is associated with L-leucine biosynthesis, proteinogenic amino acid anabolism, pigmentation, asexual and sexual reproduction, homologous recombination, and morphogenesis. It localises to the isopropylmalate isomerase complex, mitochondria, and cytosol. Phenotypic associations include decreased sporulation, abnormal colony appearance, auxotrophy, altered carbon and nitrogen source utilisation, reduced anaerobic and respiratory growth, increased telomere length and mutation frequency, decreased UV and acid pH resistance, increased oxidative stress resistance, and decreased hyperosmotic stress resistance. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.