ABC4 — Fusarium graminearum PH-1

Summary

FgABC4 (ABC4) on chromosome 4 of Fusarium graminearum PH-1 encodes an ABC-type transporter with ATP hydrolase activity, belonging to the ABC_transporter-like family and containing an AAA+_ATPase domain. The gene is associated with ABC-type phytochelatin and xenobiotic transporter activities, and its product localises to the vacuolar membrane, fungal-type vacuole, Golgi, endoplasmic reticulum and plasma membrane. FgABC4 is associated with cellular detoxification of cadmium ion, response to metal and toxic substances, glutathione transport into the vacuole, PC2 import into the vacuole, xenobiotic detoxification by transmembrane export, secretion, membrane transport, demethylation, sexual reproduction, and the anabolism of cichorine and sterols. Related genes in other species connect the family to multidrug transport.