AFG1 — Fusarium graminearum PH-1

Summary

FgAFG1 on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with an ATPase_AFG1-like domain and P-loop_NTPase domain, possessing ATP hydrolase activity and ATP binding. The gene is annotated to mitochondrial protein quality control and protein quality control (PQC), and is associated with NO storage. Its product localises to mitochondria and the cytoplasm. FgAFG1 is linked to numerous phenotypes including abnormal respiratory metabolism, increased mitochondrial rho- mutation frequency, absent mitochondrial genome maintenance, increased hyperosmotic stress resistance, delayed G1 cell cycle progression, increased mitotic recombination, increased chitin deposition, decreased biofilm formation, decreased sporulation efficiency, increased innate thermotolerance, and increased replicative lifespan, among others. Studies of related genes in other species connect the family to respiratory growth and protein distribution.