GANB — Fusarium graminearum PH-1

Summary

FgGANB (GANB, GPAB) on chromosome 4 of Fusarium graminearum PH-1 encodes a fungal G-protein alpha subunit, a member of the Fungi_Gprotein_alpha family that includes a GproteinA_insert domain and P-loop_NTPase domain. The encoded protein possesses GTPase activity, GTP binding, adenylate cyclase activator activity, G protein-coupled receptor binding, and G-protein beta/gamma-subunit complex binding. It is associated with the heterotrimeric G-protein complex and cytoplasm. This gene is linked to GPCR signaling pathways, including the adenylate cyclase-activating GPCR signaling pathway and glucose-sensing PKA pathway. It is associated with sexual reproduction, ascospore formation, conidia formation, pseudohyphal growth, invasive growth in response to glucose limitation, biofilm formation, toxin anabolism, nitrogen fixation, phosphate metabolism, pheromone response, and negative regulation of transcription by RNA polymerase II. Studies of related genes in other species link the family to germination rate and altered virulence, including reduced virulence.