HIS3 — Fusarium graminearum PH-1

Summary

FgHIS3 (FGRAMPH1_01G26597) on chromosome 4 of Fusarium graminearum PH-1 encodes a histidinol-phosphate transaminase, a pyridoxal phosphate-dependent aminotransferase of the HisP_aminotrans family. The enzyme is annotated to histidine anabolism and localises to the cytosol. The gene is associated with a wide range of phenotypes, including abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy and mitophagy, abnormal liquid culture appearance, decreased respiratory growth and nitrogen utilisation, increased stress and metal resistance, increased replicative and chronological lifespan, altered competitive fitness and chemical resistance, and abnormal protein/peptide accumulation. Related genes in other species are linked to oxidative stress response, mitotic recombination, endocytosis, vacuolar morphology and vegetative growth.