ALG3 — Fusarium graminearum PH-1

Summary

FgALG3 (FGRAMPH1_01G26583) on chromosome 4 of Fusarium graminearum PH-1 encodes a glycosyltransferase of the ALG3 family with dolichyl-phosphate-mannose-dependent alpha-1,3-mannosyltransferase activity, localised to the lumenal side of the endoplasmic reticulum membrane. The gene is associated with protein N-linked glycosylation, oligosaccharide-PP-dolichol assembly, and glycoprotein anabolism. Phenotypic associations include abnormal vegetative growth, sporulation, cell wall morphology, and actin cytoskeleton; decreased cytokinesis, budding index, and sporulation efficiency; increased cell death and innate thermotolerance; delayed endocytosis; arrested cell cycle at G2/M phase; and altered carbon and nitrogen source utilisation. The gene is also linked to ALG11, SLP1, GSC2, and RHO1. Related genes in other species connect the family to alpha-1,3-mannosyltransferase activity (EC 2.4.1.258) and increased protein secretion.