BD — Fusarium graminearum PH-1

Summary

FgBD (FGRAMPH1_01G26295) on chromosome 4 of Fusarium graminearum PH-1 encodes a small GTPase of the Ras-type family, possessing GTPase activity, GTP binding and G protein activity. The gene is associated with Ras protein signal transduction, regulation of conidium formation, spore germination, sexual reproduction, hyphal growth, establishment or maintenance of cell polarity, and nitrate metabolism. It is linked to the plasmalemma. Phenotypic associations include decreased vacuolar transport rate, absent bipolar budding, decreased redox state, increased mating-type switching, decreased entry into G0, absent osmotic and oxidative stress resistance, delayed nuclear export, abnormal pheromone production, increased protein transport, delayed cell cycle progression in telophase, absent prion inheritance, decreased budding rate, decreased flocculation, and absent transposable element transposition. Studies of related genes in other species link the family to reduced virulence and the oxidative stress response.