pkc1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G26573 (symbol pkc1) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with novel protein kinase C activity, possessing serine/threonine kinase, C2, HR1, and C1-like domains, and binding ATP and zinc. The gene is associated with positive regulation of the cell integrity MAPK cascade, mitotic cytokinesis site selection, and cytoplasmic mRNA processing body assembly. It is linked to regulation of cell shape, actin cytoskeleton organization, fungal-type cell wall biogenesis, and asexual reproduction. The encoded protein localizes to the actomyosin contractile ring, division septum, cell tip, and stress granules. Studies of related genes in other species link the family to reduced virulence.