PEX12 — Fusarium graminearum PH-1

Summary

FgPEX12 (FGRAMPH1_01G26343) on chromosome 4 of Fusarium graminearum PH-1 encodes a peroxisomal membrane protein with a Pex_N domain and a Znf_RING/FYVE/PHD domain, possessing ubiquitin ligase and ubiquitin-protein transferase activity. The gene is associated with peroxisome matrix protein import and receptor recycling, protein ubiquitination, homologous recombination, and lipid metabolism. It localizes to the peroxisomal import pore and peroxisome membrane. Phenotypic associations include abnormal peroxisomal transport and morphology, altered mating response, increased pheromone sensitivity, decreased chitin deposition, abnormal cell cycle progression, increased exponential growth rate, abnormal vegetative growth and sporulation, increased mutation frequency, and altered carbon source utilization. The gene is linked to other peroxins including PEX5, PEX8, PEX14, and PEX19. Studies of related genes in other species connect the family to acid sensitivity.