PSE1 — Fusarium graminearum PH-1

Summary

FgPSE1 (PSE1) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with importin-beta family domains including importin_rep and ARM-type fold, and is annotated as a nuclear import signal receptor with NLS binding and small GTPase binding activities. The gene is associated with nuclear import and export, regulation of mitosis and protein desumoylation, mRNA-nucleus export, and asexual reproduction. It localizes to the nucleus, nuclear periphery, envelope, cytoplasm, and cytosol. Phenotypic associations include abnormal nuclear import and export, decreased cell cycle progression in M and S phases, delayed chromosome segregation, arrested late anaphase, absent pheromone sensitivity, decreased adhesion, sterility, increased polyploidy and aneuploidy, abnormal colony shape and bud neck morphology, and absent spore germination. Studies of related genes in other species link the family to reduced virulence and abnormal cytokinesis.