CCC1 — Fusarium graminearum PH-1

Summary

FgCCC1 (FGRAMPH1_01G25775) on chromosome 4 of Fusarium graminearum PH-1 encodes a member of the Ccc1 family of vacuolar membrane transporters with manganese ion transmembrane transporter activity. The gene is associated with cellular manganese ion homeostasis, iron transport, detoxification, and vacuolar membrane localisation. It is linked to numerous phenotypes including abnormal prion state, decreased fermentative and respiratory metabolism, decreased anaerobic growth, decreased pheromone production, increased acid and osmotic stress resistance, abnormal septum formation and cytokinesis, decreased bipolar budding, increased S-phase duration, absent mitophagy and endocytosis, abnormal mitochondrial distribution and genome maintenance, abnormal peroxisomal morphology, and decreased utilisation of iron sources. Related genes in other species connect the family to iron sensitivity and iron concentration traits, as well as abnormal cell cycle progression.