AOX1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G25027 (AOX1) on chromosome 4 of Fusarium graminearum PH-1 encodes a member of the glucose-methanol-choline (GMC) oxidoreductase family, characterized by GMC_OxRdtase and FAD/NAD-binding domains. The enzyme exhibits alcohol oxidase and pyranose dehydrogenase (acceptor) activities, along with oxidoreductase activity acting on CH-OH group donors, and binds FAD or FADH2 and lipids. It is associated with methanol metabolism and methane breakdown, as well as programmed cell death and cell death. The protein localizes to the peroxisomal lumen and extracellular space. Studies of related genes in other species link the AOX1 family to reduced virulence.