BD — Fusarium graminearum PH-1

Summary

FgBD (FGRAMPH1_01G24899) on chromosome 4 of Fusarium graminearum PH-1 encodes a small GTPase of the Ras-type family, possessing GTP and GDP binding, GTPase activity, and protein serine/threonine kinase activator activity. This gene is associated with Ras protein signal transduction and the cAMP/PKA signaling cassette, and is linked to negative regulation of asexual sporulation, cellular responses to glucose and nitrogen starvation, cell-substrate adhesion, biofilm formation, and mitigation of host defenses. It has been connected to phenotypes including altered vacuolar transport, bipolar budding, redox state, mating-type switching, osmotic and oxidative stress resistance, and cell cycle progression. Localization evidence places the product at the plasma membrane, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.