CPR2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G24825, designated CPR2 in Fusarium graminearum PH-1 on chromosome 4, encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with cyclosporin A binding activity. The product is localised to the endoplasmic reticulum, cytoplasm, membrane, fungal-type vacuole, and extracellular space. CPR2 is associated with asexual and sexual reproduction, protein folding, and the biosynthesis of fumonisin, sphingolipids, and mycotoxins. Phenotypic associations include abnormal colony color, cell cycle arrest at metaphase-anaphase, altered endocytosis, increased cell death, reduced invasive growth, increased pseudohyphal growth, decreased osmotic stress resistance, and increased sporulation efficiency. Studies of related genes in other species link the family to reduced virulence and altered survival in stationary phase.