PRE6 — Fusarium graminearum PH-1

Summary

FgPRE6 (FGRAMPH1_01G24415) on chromosome 4 of Fusarium graminearum PH-1 encodes a proteasome alpha-type subunit. The gene is associated with proteasome degradation, proteasomal ubiquitin-independent protein catabolic process, proteasome assembly, nuclear import, and proteasomal protein catabolic process. The product localises to the proteasome core complex, alpha-subunit complex, proteasome storage granule, nuclear periphery, cytoplasm, cytosol, and nucleus. Associations link FgPRE6 to cell cycle progression, including G1/S and G2/M phase transitions, cytokinesis, chromosome segregation, and increased vegetative growth rate. It is also linked to decreased spore germination, altered chitin deposition, increased stationary-phase survival, abnormal redox state, and reduced utilisation of iron and nitrogen sources. Studies of related genes in other species connect the family to proteasome function and cell cycle control.