ACT — Fusarium graminearum PH-1

Summary

FgACT (ACT) on chromosome 4 of Fusarium graminearum PH-1 encodes an actin protein, a structural constituent of the cytoskeleton with ATP-binding and hydrolase activity. It is associated with actin depolymerization, endocytosis, and both asexual and sexual reproduction, as well as chromatin remodeling, DNA repair-dependent transcription regulation, and homeostasis. The protein localizes to the actin cytoskeleton, actomyosin contractile ring layers, hyphal tip, and perinuclear region, and is part of the Ino80 and TIP60 complexes. Phenotypic associations include delayed protein secretion and cytokinesis, decreased cell cycle progression, abnormal sporulation efficiency, absent cell fusion and anaerobic growth, and altered prion inheritance. Studies of related genes in other species link the actin family to reduced virulence and oxidative stress response.