TSC2 — Fusarium graminearum PH-1

Summary

FgTSC2 (FGRAMPH1_01G24129) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a Rap/Ran-GAP domain and a tuberin N-terminal domain, and has GTPase-activating protein (GAP) activity. The gene is associated with negative regulation of TOR signaling and TORC1 signaling, positive regulation of autophagy, regulation of small GTPase-mediated signal transduction, upregulation of L-leucine import, activation of L-arginine uptake, and negative regulation of G1/S transition of the mitotic cell cycle. The encoded protein localises to the TSC1-TSC2 complex, the cell division site, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to growth control and nutrient sensing, though these associations are not yet established in F. graminearum.